Recombination at Double-Strand Breaks and DNA Ends
Identifieur interne : 000C97 ( Main/Exploration ); précédent : 000C96; suivant : 000C98Recombination at Double-Strand Breaks and DNA Ends
Auteurs : Gareth A. Cromie [Royaume-Uni] ; John C. Connelly [Royaume-Uni] ; David R. F. Leach [Royaume-Uni]Source :
- Molecular Cell [ 1097-2765 ] ; 2001.
English descriptors
- Teeft :
- Acad, Bacteriophage, Biol, Branch migration, Cell cycle, Cell cycle progression, Cell division, Cerevisiae, Chem, Chromatid, Chromosomal, Chromosome, Coli, Cromie, Crossover, Crossover products, Different kinds, Doublestrand breaks, Dsbs, Duplex, Embo, Endonuclease, Escherichia, Escherichia coli, Eukaryote, Eukaryotic, Eukaryotic cells, Exonuclease, Free ends, Gellert, Genes cells, Genetic recombination, Genetic requirements, Genome, Haber, Helicase, Holliday, Holliday junction, Holliday junction resolution, Homolog, Homologs, Kleckner, Kowalczykowski, Ligase, Mammalian cells, Meiosis, Meiotic, Meiotic recombination, Microbiol, Mitotic, Molecular cell, Mutation, Natl, Nhej, Nijmegen breakage syndrome, Noncrossover, Noncrossover product, Noncrossover products, Nuclease, Overhang, Pathway, Paull, Proc, Processive, Processive replication fork, Processive replication forks, Reca, Reca protein, Recbcd, Recbcd enzyme, Recombination, Recombination reactions, Recombinational, Recombinational repair, Repair proteins, Replication, Replication fork, Replication forks, Replication protein, Ruvabc, Ruvb, Ruvb rings, Ruvc, Saccharomyces, Saccharomyces cerevisiae, Sbccd, Sister chromatid, Strand, Strand breaks, Strand exchange, Strand exchange protein, Strand invasion, Trends biochem, Vertebrate cells, Yeast.
Abstract
The recombination mechanisms that deal with double-strand breaks in organisms as diverse as phage, bacteria, yeast, and humans are remarkably conserved. We discuss conservation in the biochemical pathways required to recombine DNA ends and in the structure of the DNA products. In addition, we highlight that two fundamentally distinct broken DNA substrates exist and describe how they are repaired differently by recombination. Finally, we discuss the need to coordinate recombinational repair with cell division through DNA damage response pathways.
Url:
DOI: 10.1016/S1097-2765(01)00419-1
Affiliations:
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We discuss conservation in the biochemical pathways required to recombine DNA ends and in the structure of the DNA products. In addition, we highlight that two fundamentally distinct broken DNA substrates exist and describe how they are repaired differently by recombination. Finally, we discuss the need to coordinate recombinational repair with cell division through DNA damage response pathways.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Cromie, Gareth A" sort="Cromie, Gareth A" uniqKey="Cromie G" first="Gareth A." last="Cromie">Gareth A. Cromie</name></region><name sortKey="Connelly, John C" sort="Connelly, John C" uniqKey="Connelly J" first="John C." last="Connelly">John C. Connelly</name><name sortKey="Leach, David R F" sort="Leach, David R F" uniqKey="Leach D" first="David R. F." last="Leach">David R. F. Leach</name><name sortKey="Leach, David R F" sort="Leach, David R F" uniqKey="Leach D" first="David R. F." last="Leach">David R. F. Leach</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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